Bone Abstracts

We assessed whether systemic Strontium ranelate (SrRan) administration accelerates the healing of a bone defect and could modulate local bone cellular activities. Proximal tibia bone defects were created in 6-month-old female rats, which received then orally SrRan (625 mg/kg per day, 5/7 days) or vehicle (controls) for 4, 8, or 12 weeks. Bone samples were analysed by micro-computed tomography and histomorphometry in various compartments, ie metaphyseal second spongiosa (MC), a...

see PP361....

We previously demonstrated that an isocaloric low protein diet attenuates the bone anabolic response to GH. Whether such a dietary manipulation could affect the bone anabolic effects of PTH was assessed. We studied 6-month-old female rats pair fed with isocaloric diets with a low protein (2.5% casein, LP) or normal protein content (15% casein, NP) for 2 weeks. Then, the animals were treated with 5 or 40 μg/kg recombinant human amino-terminal fragment PTH(1–34) (PTH-5...